Thiazolidinone, a saturated form of thiazole with carbonyl group on fourth carbon, has been considered as a magic moiety (wonder nucleus) which posses almost all types of biological activities. This diversity in the biological response profile has attracted the attention to explore this skeleton to its multiple potential against several activities. Present article is sincere attempt to suggest chemistry, synthesis spectral studies and applications of 4-thiazolidinone, further docking studies were performed on synthesized novel compounds by using AutoDock 4.0 MGL tools software packages. This molecular modeling study allowed confirming the preferential binding mode of novel 4-thiazolidinones inside the active site.
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